バイオセンサは、動物の脳内神経化学物質の濃度変化をリアルタイムで監視するために使用される。検出物質によってはグルタミン酸（Glutamate）、グルコース（glucose）、乳酸（lactate）、エタノール（ethanol）に使用できる。覚醒活動状態における動物中枢神経系神経化学物質の濃度変化を記録するために使用できるデータ収集器とソフトウェアを配合した。通常、行動学と生理活動の研究に用いられ、薬物スクリーニングと神経薬理学の研究の理想的なツールである。

Biosensors monitor real-time changes in neurochemical concentrations. With Pinnacle's turn-key electronic and software systems, users can record and analyze second-by-second concentration changes (not basal level) of CNS neurochemicals in freely moving animals . Biosensors are commonly used forin vivomonitoring during behavioral and physiological activities. They are also ideal for drug screening and investigating the neuropharmacological effects of different compounds.

BIOSENSOR TYPES

Pinnacle offers glutamate,glucose,lactateand ethanol biosensors.
All biosensors sold by Pinnacle are for non-human use only.

BIOSENSOR DIAGRAM

Pinnacle biosensors function by the enzyme-mediated processing of the analyte of interest. This results in the production of hydrogen peroxide that is then detected by oxidation at a Pt-Ir electrode. Electroactive interferents present in the brain are excluded via a passive selective membrane and through active removal when necessary.

CARBON FIBER SENSORS

CARBON FIBER SENSORS (CFSs) are used in conjunction with Pinnacle’s tethered and wireless potentiostats to measure the presence of total biogenic amines in the brain using fixed potential amperometry (FPA). They are also used with fast scan cyclic voltammetry (FSCV) systems. All Pinnacle CFSs require an Ag/AgCl reference electrode (7065). The sensors are 34 µm in diameter and 0.5 mm in length.

GUIDE CANNULAS

Pinnacle recommends the use of a guide cannula system for optimal results when implanting and recording from sensors in the brain of a freely moving animal. Biosensors are compatible with several guide cannula types. Single-barrel, tri-barrel, and BASi cannluas are available for rats; BASi cannulas are available for mice. Sensors with no cannulas are also available for purchase.

BIOSENSOR CALIBRATION
In order to relate the current changes measured by a biosensor to actual changes in analyte concentration, it is necessary to calibrate the biosensor at the conclusion of an experiment. The process also confirms the integrity and selectivity of the sensors. Pinnacle offers a number of in vitro calibration systems that allow the simultaneous calibration of four to eight biosensors. Select the calibration kit that matches the hardware system and cannula type used in your experimental setup.

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